Hematopathology

2008 WHO classification of lymphomas

New WHO Classification of Lymphoid Neoplasms (2008)

Precursor Lymphoid Neoplasms

B lymphoblastic leukemia / lymphoma NOS
B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities
B lymphoblastic leukemia / lymphoma with t(9;22); bcr-abl1
B lymphoblastic leukemia / lymphoma with t(v;11q23); MLL rearranged
B lymphoblastic leukemia / lymphoma with t(12:21); TEL-AML1 & ETV6-RUNX1
B lymphoblastic leukemia / lymphoma with hyperploidy
B lymphoblastic leukemia / lymphoma with hypodiploidy
B lymphoblastic leukemia / lymphoma with t(5;14); IL3-IGH
B lymphoblastic leukemia / lymphoma with t(1;19); E2A-PBX1 & TCF3-PBX1
T lymphoblastic leukemia / lymphoma

Mature B-Cell Neoplasms

Chronic lymphocytic leukemia / small lymphocytic lymphoma
B-cell prolymphocytic leukemia
Splenic marginal zone lymphoma
Hairy cell leukemia
Lymphoplasmacytic lymphoma / Waldenstrom macroglobulinemia
Heavy chain disease
Plasma cell myeloma
Solitary plasmacytoma of bone
Extraosseous plasmacytoma
Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) type
Nodal marginal zone lymphoma
Follicular lymphoma
Primary cutaneous follicular lymphoma
Mantle cell lymphoma
Diffuse large B-cell lymphoma, NOS
(T-cell / histiocyte-rich type; primary CNS type ; primary leg skin type & EBV+ elderly type)
Diffuse large B-cell lymphoma with chronic inflammation
Lymphomatoid granulomatosis
Primary mediastinal large B-cell lymphoma
Intravascular large B-cell lymphoma
ALK+ large B-cell lymphoma
Plasmablastic lymphoma
Large B-cell lymphoma associated with HHV8+ Castleman disease
Primary effusion lymphoma
Burkitt lymphoma
B cell lymphoma, unclassifiable, Burkitt-like
B cell lymphoma, unclassifiable, Hodgkin lymphoma-like

Mature T-Cell & NK-Cell Neoplasms

T-cell prolymphocytic leukemia
T-cell large granular lymphocytic leukemia
Chronic lymphoproliferative disorder of NK-cells.

Aggressive NK-cell leukemia
Systemic EBV+ T-cell lymphoproliferative disorder of childhood
Hydroa vacciniforme-like lymphoma
Adult T-cell lymphoma/leukemia
Extranodal T-cell/NK-cell lymphoma, nasal type
Enteropathy-associated T-cell lymphoma
Hepato-splenic T-cell lymphoma
Subcutaneous panniculitis-like T-cell lymphoma
Mycosis fungoides
Sézary syndrome
Primary cutaneous CD30+ T-cell lymphoproliferative disorder
Primary cutaneous gamma-delta T-cell lymphoma
Peripheral T-cell lymphoma, NOS
Angioimmunoblastic T-cell lymphoma
Anaplastic large cell lymphoma, ALK+ type
Anaplastic large cell lymphoma, ALK- type

Hodgkin lymphoma (Hodgkin disease)

Nodular lymphocyte-predominant Hodgkin lymphomas

Classic Hodgkin lymphomas
Nodular sclerosis Hodgkin lymphoma
Lymphocyte-rich classic Hodgkin lymphoma
Mixed cellularity Hodgkin lymphoma
Lymphocyte depletion Hodgkin lymphoma

Post-Transplant Lymphoproliferative Disorders (PTLD)

Plasmacytic hyperplasia
Infectious mononucleosis like PTLD
Polymorphic PTLD
Monomorphic PTLD (B & T/NK cell types)
Classic HD type PTLD

Histiocytic and Dendritic Cell Neoplasms

Histiocytic sarcoma
Langerhans cell histiocytosis
Langerhans cell sarcoma
Interdigitating dendritic cell sarcoma
Follicular dendritic cell sarcoma
Fibroblastic reticular cell tumor
Indeterminate dendritic cell sarcoma
Disseminated juvenile xanthogranuloma

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