New WHO Classification of Lymphoid Neoplasms (2008)
Precursor Lymphoid Neoplasms
B lymphoblastic leukemia / lymphoma NOS
B lymphoblastic leukemia / lymphoma with recurrent genetic abnormalities
B lymphoblastic leukemia / lymphoma with t(9;22); bcr-abl1
B lymphoblastic leukemia / lymphoma with t(v;11q23); MLL rearranged
B lymphoblastic leukemia / lymphoma with t(12:21); TEL-AML1 & ETV6-RUNX1
B lymphoblastic leukemia / lymphoma with hyperploidy
B lymphoblastic leukemia / [...]
Molecular testing for diagnosis of lymphoma and leukemia
The advent of molecular biological techniques has led to a radical improvement in the evaluation of haematological disorders and offers exciting future prospects. In particular it has led to the improved recognition of distinct clinicopathological entities defined by a combination of morphological, immunophenotypic and chromosomal features. Antibody-based techniques, [...]
Flow cytometers (from Wikipedia)
Modern flow cytometers are able to analyse several thousand particles every second, in “real time”, and can actively separate and isolate particles having specified properties. A flow cytometer is similar to a microscope, except that instead of producing an image of the cell, flow cytometry offers “high-throughput” (for a large number of [...]
Application of immunohistochemistry in the diagnosis of non-Hodgkin and Hodgkin lymphomas.
[My paper] Russell A Higgins, et al.
Context.-Beginning with the immunologic classifications of Lukes and Collins and Kiel and culminating in the Revised European-American Lymphoma and World Health Organization classifications, the diagnosis of lymphoid tumors relies heavily on the determination of cell lineage, maturation, and function, [...]
BY ROBERT H. CARLSON oncology times • september 10, 2008
While the 2008 revision of the World Health Organization Classification of Tumors of the Hematopoietic and Lymphoid Tissues does not contain major changes from the 2001 edition, it may answer questions clinicians still have, said Nancy Lee Harris, MD, Professor of Pathology at Massachusetts [...]